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We hypothesized that TPH-2 variants could influence the function of SCN in MDD patients with early wakening symptom. Methods: One hundred and eighty five MDD patients (62 patients without early wakening and 123 patients with early wakening) and 64 healthy controls participated in this study. Blood samples were collected and genotyping …
Fig. 1. Synthesis and metabolism of serotonin. L-tryptophan (Trp) is converted by Trytophan hydroxylases (TPH) 1 and 2 to 5-hydroxytryptophan (5-HTP) with molecular oxygen and (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin (BH 4) as co-substrates. 5-HTP is metabolized to 5-HT by aromatic amino acid decarboxylase (AADC).
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Tryptophan hydroxylase (TPH) catalyzes the rate-limiting step in the synthesis of serotonin (5-hydroxytryptamine; 5-HT), 1 a neurotransmitter that plays an important role in the regulation of mood ...
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In addition, a highly significant association with ADHD was observed between a haplotype made of allele T of rs1843809 and allele C of rs1386493 (χ 2 =11.62, df=1, P=0.0007; global χ 2 =19.5, df ...
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Tryptophan hydroxylase-2 (TPH-2) is a protein coding gene that belongs to the biopterin-dependent aromatic amino acid hydroxylase family and is the rate-limiting isozyme in the biosynthesis of neuronal serotonin (5-HT) (Zhang et al., 2004). TPH-2 gene was found to be primarily expressed in the serotonergic cells of the raphe nucleus (Bach ...
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Tryptophan hydroxylase (TPH), converts tryptophan in the brain to 5-hydroxytryptophan (5-HTP), the immediate precursor of 5-HT (Fig. 1 A; Lovenberg et al 1967, Kuhn et al 1979).Because TPH is the rate-limiting enzyme in 5-HT synthesis, has low expression in most tissues and is relatively unstable, minor changes in TPH abundance …
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